Associate Principal Scientist Oncology, Pharmacology and Screening

Debiopharmis an independent biopharmaceutical company based in Switzerland with an ongoing commitment to research in oncology and bacterial infections in order to improving patient outcomes and quality of life. Our main activities include drug development, drug manufacturing and digital health investment. Debiopharm International SA aims to develop innovative therapies that target high unmet medical needs. Bridging the gap between disruptive discovery products and real-world patient reach, we identify high-potential compounds for in-licensing, clinically demonstrate their safety and efficacy and then select large pharmaceutical commercialization partners to maximize patient access globally.

Here:https://apply.workable.com/debiopharm-group-sa/

For our Translational Medicine organization based at our Headquarters in Lausanne, we are looking for a

Associate Principal Scientist Oncology, Pharmacology and Screening

In this role, you will represent the Pharmacology & Screening (P&S) function in Translational Medicine team and participate in the development of new innovative medicines in Oncology

The mission of the Pharmacology and Screening unit is to understand how drugs work, to guide and accelerate drug development. At Debiopharm you will be at the forefront of the fight against cancer, and you will have the opportunity to work on a large range of new innovative medicines for patients. Efficacy is our mode of action, saving lives our collective target.

Your responsibilities will be but not limited to:

• Represent the Pharmacology and Screening function in Translational Medicine Teams, Global Project Teams and Clinical Study teams and contribute to the elaboration of the drug development strategy and lead cross-functional teams or projects.
• Design, plan, manage and report primary and secondary pharmacology studies performed in Contract Research Organizations:
  • In vitro/in vivo pharmacology compounds selection and profiling, including off-target characterization
  • Proof of concept in vivo studies – PK/PD
  • Mechanism of action studies
• Select, implement, and manage the clinical pharmacodynamic biomarkers assays, data analyses and reporting according to GCPs and GCLPs and you represent Pharmacology and Screening function in clinical study teams
• Participate in the preparation of investigator drug brochures, informed consent forms, lab manuals, clinical protocols and reports
• Identify the intellectual property, inventions and innovation opportunities, and collaborate with legal department to feed DPI’s patent portfolio
• Responsible for the preparation of the pharmacology documentation for health authorities
• Participate in external scientific communications
• Participate in due diligence and contribute to in/out licensing activities

• PhD in the field of biomedical research biomedical engineering or equivalent and at least 5-7 years experience in translational pharmacology in Oncology in pharma or biotech
• Knowledge of GCP and ICH guidelines, animal welfare regulations, and relevant regulatory guidelines
• Experience in selection and management of Contract Research Organizations
• Excellent communication skills (oral and written) in English
• You are solution-oriented, resilient to push forward the R&D projects and look to work on complex and innovative compounds, willing to be hands-on in activities
• You have excellent commend of data analysis and visualization tools and have good IT skills
• You are used in working in cross-functional team and fast-paced environment and are a team player, looking to tackle challenges together with your team

• An international and highly dynamic environment, with a long term vision.
• The opportunity to join a successful company, at the forefront of the most advanced scientific developments in the industry and be exposed to many areas within clinical development and the pharmaceutical industry.
• The possibility to be in a company in which innovation, people and entrepreneurship are the fundamentals of its success.

The use of external staffing agencies or recruiters requires prior approval from our Human Resources Department. The Human Resources Department at Debiopharm requests external staffing agencies or recruiters not to contact Debiopharm employees or members of the Board of Directors directly in an attempt to present candidates.

Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the external staffing agency or recruiter does not create any implied obligation on the part of Debiopharm.

Debiopharm will not accept unsolicited resumes from any source other than candidates themselves for either current or future positions.