Position: Mid-Senior level

Job type: Full-time

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Job content

Matterhorn Biosciences is looking for a (Senior) Research Associate, CMC

Matterhorn Biosciences is a preclinical stage biotechnology company pioneering the discovery and development of novel T cell therapy for cancer treatment. We are an exciting, motivated group of scientists who are determined to make a difference for modern human medicine.

Your Role Will Be Comprised Of

As we continue to build the R&D team, we are seeking to appoint a highly motivated researcher to join our team as a (Senior) Research Associate, CMC supporting our novel TCR discovery workflow in house. The role will require the precise application of a diverse range of laboratory-based skills. As such, the successful candidate will have significant research experience on T cell immunology, cancer cell culture and flow cytometry. The ideal candidate should be highly motivated, enthusiastic with a positive “can do” attitude, hands-on, strong organizational skills, able to work independently and enjoy fast-paced, collaborative, and vibrant startup culture.You will further strengthen our team by contributing to the development of Matterhorn Biosciences. You will help increase the biological understanding of programs as well as developing novel biological assays to help propel our company forward.
  • Routine cancer cell line maintenance including expansion and banking
  • Engineer cancer cell lines to express or knock out target antigen
  • Engineer T cells to express TCRs of interest using lentiviruses and perform TCR expression analysis by flow cytometry
  • Perform immune cell assays such as tumor cell killing, cytokine production and T cell proliferation
  • Isolate primary immune cells from blood products such as leukopaks
  • Analyze data, make figures for presentation, and present at group and company meetings
As a member of our growing team, you will increasingly be expected to take responsibility for the design and completion of experiments including careful documentation and presentation of results in internal and external meetings. You have significant laboratory experience, along with a good understanding of the assays used in a molecular and cellular immunology laboratory. Specifically, we are looking for candidates with the following:
  • A Bachelor’s degree with 3+ years or Master’s degree and 2+ years of relevant lab experience, preferably in biopharmaceutical or biotechnology industry
  • Strong experience with cancer cell culture and understanding of cancer cell biology
  • Experience in T cell immunology and understanding of molecular biology a plus
  • Proficiency in molecular biology techniques and cell engineering is preferred, experience with flow cytometry, ELISA and cytotoxicity assays using Incucyte desired
  • Know-how experimental design and ability to work independently
  • Able to work in a highly flexible environment
  • Able to communicate with team members and cross-functional project teams
  • Good English communication skills, both oral and written
  • Offices: Our well-equipped laboratories and offices are located at the Tech Park Basel, a premier address for early-stage start-ups.
  • Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
  • Flexible Working: We support flexible working as appropriate.
  • Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
  • Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
  • Food: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
  • Coffee: Meet up with your colleagues and grab free coffee.
  • Development: We support the individual development of our employees.
  • German Lessons: For our international employees we support German lessons to speed up integration.
  • Creativity: We offer an innovative and creative environment.
  • People: We are an international and diverse team with talented and passionate people.
  • Fun: From time-to-time we organise cool off-site summer and winter team events.
To apply, please send us this application form together with your CVand Cover Letter.
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Deadline: 02-05-2024

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