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Senior Research Associate - Discovery and Research - Ophthalmology
전망: 163
갱신일: 21-03-2024
수평: Mid-Senior level
직업 종류: Full-time
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작업 내용
Our client, Tenpoint Therapeutics Ltd, a company founded in 2020 is dedicated to the creation and development of novel, innovative cell-based / regenerative therapies for the treatment of ocular diseases. Tenpoint is committed to creating an inclusive, diverse, supportive work environment and fosters the personal / professional growth of their employees. They will be establishing one of their laboratories in Allschwil, Switzerland and will be building-up the research team to contribute to the development of growing Tenpoint’s portfolio programs, giving the successful candidate exposure to all stages of drug discovery. Working Location: AllschwTasks
- Support all research activities and contribute to the development of growing Tenpoint’s portfolio programs
- Cultivation of healthy and engineered human iPS/ES cells, maintenance and differentiation to retinal pigment epithelial cells (RPE), retinal organoids and co-culture of two or three cell types.
- Charactization and functional analysis of retinal organoids/RPE using fluorescence microscopy, image analysis, flow cytometry, FACS, MACS, fluorescence/luminance-plate reader, gene expression analysis, western blot & histology.
- Perform in vitro pharmacology studies, development & establishment cell-based assays to evaluate mechanisms of action.
- Work independently with minimal supervision. Plan and execute experiments, analyse, interpret, accurately document (electronic lab notebook) and communicate data in team meetings.
- Involvement in cell culture lab management and organization.
- Completed training as a BTA/CTA/MTA/biology lab technician with work experience or BSc/MSc in Life sciences (biology, biotechnology, genetic engineering) or other relevant area.
- Background in ophthalmology and extensive experience (5 years) human iPSC/ESCs and its differentiation different ocular cell types (retinal organoids, RPE and others).
- Experience in drug discovery research/pharma/biotech & complement biology is a plus.
- Hands-on experience in assay development, co-culture of multiple cell types (example: endothelial cells), luminescence/fluorescence plate-based assays, flow cytometry, cell sorting (MACS / FACS), cryo-sectioning, immunohistochemistry, fluorescence microscopy, image analysis, gene and protein analysis.
- Knowledgeable with various genetic perturbation methods (gene editing, RNAi, viral transduction etc.) and validation assays.
- Team-oriented, responsible and reliable personality with a positive “can-do” attitude.
- Willingness to learn a variety of new techniques and technologies and flexible to adapt to rapidly changing priorities and deadlines.
- A stimulating and challenging position in a fast-paced environment
- Independent work in a highly motivated team
- An open, dynamic, collaborative and multi-disciplinary environment
- Attractive employment conditions, competitive remuneration and social benefits
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마감 시간: 05-05-2024
무료 후보 신청 클릭
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