Senior Scientist - preclinical CMC Drug Substance

작업 내용

In Roche´s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The position is located in preclinical Chemistry, Manufacturing and Controls, a department within the Therapeutic Modalities function, where the development of robust and innovative API synthesis and drug products to supply and enable key preclinical activities paves the way towards Entry Into Human. We are CMC experts and together with our discovery functions partners, we generate scientific and technical knowledge to assess the developability of drug candidates. We build our strength on a broad diversity of enthusiastic technical experts, pharmacists, chemists and analytical chemists delivering and innovating in the space of small molecules, peptides and oligonucleotides.

Job Mission

We are offering an outstanding opportunity for an experienced organic chemist to work with a multidisciplinary team of scientists dedicated to solving complex synthetic, process research, scale-up and supply challenges to support our early R&D portfolio.

Your Impact

• Developing scalable synthetic routes and processes (including own work in the laboratory to enable efficient, robust and safe supplies, ideally also fit for clinical phase 1 API delivery.
• Managing and coordinating all non-GMP API supply campaigns in our Kilolaboratory in support of our small molecules portfolio
• Embracing the use of new technologies and digital workflows
• Nurturing trustful relationships and effective collaboration with internal and external partners
  
  

Your Profile

You thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development. You have a keen interest in continuously building a personal network. You are resourceful and flexible in problem solving and in working in a collaborative and inclusive manner. You have a sense for ensuring that everyone has the required information at all times. You have a MS in Chemistry with 7 years of experience or a PhD in synthetic organic chemistry with relevant professional experience in chemical process R&D.

Your professional experience allows you to expertly lead chemical process R&D efforts with an emphasis on the scale-up of small molecule syntheses. You are knowledgeable in state of the art organic synthesis, technical and safety aspects relevant to drug substance supply in a kilolaboratory or pilot plant environment. You have strong oral and written communication skills and are proficient in preparing and running effective meetings. German knowledge is a plus.

Our commitment

Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.

We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

Job Level:

Individual contributor