Research Technician / Scientific Associate - Chemistry Process R&D
☞ Idorsia Pharmaceuticals Ltd.
View: 203
Update day: 26-03-2024
Location: Allschwil Basel-Landschaft BL
Category: Pharmaceutical / Chemical / Biotech
Industry:
Job type: Temps plein, Durée indeterminée
Job content
For our Chemistry Process R&D organization, we are seeking a motivated Research Technician or Scientific Associate.
Job Responsibilities
- Carrying out laboratory work ranging from route finding to multi-kilogram syntheses
- Optimizing reactions (1-100 g) by scrupulous control of reaction parameters using double-jacketed glass reactors
- Proposing alternative reaction conditions and synthesis pathways, and solve scale-up problems
- Producing Active Pharmaceutical Ingredients (API) on kilogram scale (up to 30-liter reactors) to support preclinical development
- Monitoring reaction progress and performing compound analysis using TLC, LC/MS, GC/MS, NMR, or online techniques
- Interpret analytical data and take appropriate action
- Purify reaction products using standard techniques e.g. column chromatography, prep. HPLC, crystallization, or distillation
- Performing general lab duties and maintain a high standard of order and cleanliness
- Equipment champion of a dedicated technology or equipment
- Accurate and regular documentation of experimental work using electronic lab journal
- Summarizing the weekly progress
- Drafting of Mater Operation Records (MOR)
- Ownership of parts of projects, like proposal of alternative routes for scale-up, or byproduct and impurity identification
- Present at internal meetings
Candidate’s Requirements
- Apprenticeship as laboratory technician or higher education (BSc, MSc), specialized in organic synthesis
- Excellent skills in synthetic organic chemistry including asymmetric syntheses, reaction monitoring, work-up, analysis including online monitoring, and isolation techniques
- Routine use of modern methods to purify and characterize organic compounds (e.g. column chromatography, automated column chromatography, HPLC, LC-MS, NMR, GC, etc.)
- 1-5 years of operative experience with scale-up of chemical processes preferred (kilo lab or pilot plant scale)
- Ability to plan and accurately document practical work
- Safety first attitude, compliance with process safety best practice
- Team player with good communication skills and play-to-win attitude
- Hands-on in the lab with problem-solving skills
- Flexibility for changing work assignments
- Fluent in English, both written and oral, and good knowledge of German
What Idorsia offers
- Exciting opportunities for development and professional growth within our dynamic organization
- A collaborative and solution-oriented environment where you can make a difference
- An innovative and open culture in a truly multicultural environment
- A competitive salary and generous social benefits
Work Location: Allschwil
Country: Switzerland
Business Unit: Chemistry - Chemistry Process R&D
Schedule: Fulltime
Job Type: Permanent
Job ID: 2652
Deadline: 10-05-2024
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