Job type: Full-time

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Our mission is to create novel and highly differentiated medicines. As part of Roche’s pharma research and early development unit (pRED), we are at the “birthplace” of novel therapeutic antibodies and next generation biologics, such as bispecific antibodies or fusion proteins. Our ambition is to deliver such novel molecules to patients with game changing clinical benefits. We have an international reputation for making next-generation biologics that are successful in the clinic, yet we are still humbled by the complexity and effort required for this rewarding endeavor.

Roche Innovation Center Zurich is pRED’s Center of Excellence for Cancer Immunotherapy. It boasts a multinational team of some 185 employees – many of whom are research scientists – with a dynamic, thriving biotech culture.

We are a multicultural team focussing on discovery, engineering and technical development of next generation protein-based therapeutics. We pursue bold and smart approaches and offer a competitive edge to drug design by integrating expertise in molecule engineering and excellence in process development.

Although at our research site the main focus is the development of new biotherapeutics for cancer immunotherapy, we are fully integrated in pRED, offering our expertise to all disease areas and working in a strong collaboration network across all pRED sites.

Job mission

To strengthen our team at Roche Innovation Center Zurich, we are looking for a Scientist and Matrix Leader in Drug Design with a strong background in engineering of new biotherapeutics, both by computational protein engineering and by design of in-vitro display libraries using information generated by Next Generation Sequencing and Artificial Intelligence approaches.

This position offers various opportunities to play an active role in the development of new medicines.

Your impact

You will join our team as an expert for the design and engineering of proteins by applying computational engineering and by design of in-vitro display libraries using information generated by Next Generation Sequencing and Artificial Intelligence approaches.

Within this matrix position you will highly interact with our functions on site focusing on binder generation by in-vitro display technologies and with our experts for various in-silico methods (structural biology, sequence repertoire analysis, machine-learning) at the Roche Innovation Center Munich.

You will have the opportunity to continuously evaluate and establish new innovative methods in the field of protein engineering and design to support our portfolio projects.

In addition, you will drive projects across different departments and sites to ensure that clearly defined objectives, deliverables, resource requirements are set.

You will collaborate, build and maintain close relationships with other entities within Therapeutic Modalities (TMo) or pRED at different locations (Basel, Munich).

Team player:you are an interactive person and enjoy working in a team where there are no single heroes and both successes as well as failures are accounted for by the whole team.

Innovator: you are willing to suggest and try new ideas by your own initiative. You take ownership and are able to engage people to work on something new and you take changes as an opportunity to grow.

Infinite learner: you never miss an update of your skill-set and you show a genuine curiosity to stay at the forefront of science.

Communicator: you listen to others and encourage open discussions. You are used to presenting your topics in English in a clear and convincing way to expert and non-expert audiences and to management boards.

Your profile

  • PhD in biochemistry, structural biology or related field and at least 5 years’ experience in drug discovery. A strong expertise in protein engineering, new antibody modes, scaffolds and in vitro display technologies is key

  • In-depth expertise in library design, sequence data handling, NGS and IT solutions

  • Comprehensive knowledge in 3D Modelling, scientific programming and de novo protein design

  • Experience in successfully leading projects and cross-functional activities is highly preferred

This position is also suitable for part-time work.

Our commitment

Roche commits to recognising talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

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Deadline: 04-05-2024

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