Student internship in ADME

☞ Roche

View: 147

Update day: 25-04-2024

Location: Basel Basel-Stadt BS

Category: Education / Training

Industry: Medical Equipment Manufacturing Biotechnology Research Pharmaceutical Manufacturing

Position: Entry level

Job type: Full-time

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Job content

Project aims:

Concurrence use of drugs that modulate (inhibit or induce) metabolizing enzymes may potentially alter the exposure of a victim drug where metabolism is a rate-determining step in e.g. hepatic clearance. This will cause unexpected adverse events or lack of efficacy, which limits access to new medications for a number of the patients. The scope of this internship project is to establish and qualify reasonable in vitro methodologies to evaluate time-dependent inhibition and induction for CYP enzymes at preclinical stage using human liver preparations and new cellular tools upon necessity, to support clinical pharmacology programs for compounds showing complex drug-drug interaction (DDI) properties. This research can also provide opportunities to learn about assay techniques (sample incubation and bioanalysis with system automation) and knowledge on how to evaluate DDI risks of small molecules, which has been generally deployed in our ADME chapter.

Skills:

You have basic knowledge and strong interest in enzyme inhibition/induction risk assessment and the experimental designs
  • You are familiar with common digital tools for experimental planning, and potentially gained hands-on experience with quantitative LC-MS
  • You are able to work with a proactive and strategic thinking style in close collaboration in a team of the subject matter experts

Education and Experience:

Degree (BSc/MSc) in biochemistry, drug metabolism, pharmacokinetics or equivalently relevant study area

Who we are

At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.

We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.

Roche is an Equal Opportunity Employer.

Job Level:

Entry Level
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Deadline: 09-06-2024

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