Postdoc position in Imaging Active Gene Regulation

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Update day: 04-04-2024

Location: Lausanne Vaud VD

Category: Pharmaceutical / Chemical / Biotech

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Postdoc position in Imaging Active Gene Regulation
Employer
EPFL
Location
Lausanne, Canton of Vaud (CH)
Salary
87’000 CHF per annum
Closing date
1 May 2024
Discipline
Chemistry, Life Science, Physics
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Fixed term
Qualification
PhD
Sector
Academia

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Our laboratory of Biophysical Chemistry of Macromolecules (LCBM) at the EPFL in Lausanne, Switzerland (www.epfl.ch/labs/lcbm/) offers fully funded Postdoc positionsin the field of chemical biology of gene regulation within a context of a SNSF Advanced Grant (Swiss ERC) starting in 2024.



Our main focus is to understand the structure and function of chromatin and its role in transcription regulation using a combination of chemical biology and single-molecule imaging in vitro and in cells.
Recently, our laboratory observed how pioneer transcription factors (pTFs) can access closed chromatin. Based on this study, we are now investigating molecular mechanisms of chromatin remodeling controlled by pTFs and chromatin remodelers.



In particular, our lab is starting a large-scale project, called siteSEARCH, combining genetics, chemical biology, and single-molecule biophysics in living cells to discover the fundamental mechanisms of gene regulation by pTFs. Within this project, we offer both several Postdoc positions.



Your profile:
– Strong interest in chromatin biology and mechanistic investigations of gene expression
– Experience in working in a chemistry, biochemistry or (cell-) biophysics (single-molecule or super-resolution imaging, single particle tracking).
– Good knowledge in written and oral English.
– Highly motivated for discovering new molecular mechanisms in a challenging environment.
– Interest for interdisciplinary projects.
– A passion for biophysical chemistry and genetic regulation at the highest level.



Application/selection procedure:
1. Send a Letter of motivation, a CV, a summary of previously done research and the contact information of 3 referees to beat.fierz@epfl.ch.



2. Selected candidates will be invited for a virtual interview, and, in a second round a on-site visit (including a seminar and meetings with PhD students and postdocs).



3. If you need further information, visit https://lcbm.epfl.ch/fierz/, or contact beat.fierz@epfl.ch.



Key references:

Nagpal, H., Ali-Ahmad, A., Hirano, Y. et al. CENP-A and CENP-B collaborate to create an open centromeric chromatin state. Nat Commun 14, 8227 (2023). https://doi.org/10.1038/s41467-023-43739-5

Multiplexed Single-Molecule Experiments Reveal Nucleosome Invasion Dynamics of the Cas9 Genome Editor, Makasheva et al., JACS 2021, https://doi.org/10.1021/jacs.1c06195



The mechanistic basis for chromatin invasion and remodeling by the yeast pioneer transcription factor Rap1, Mivelaz, M., et al., 2020, Mol Cell., https://doi.org/10.1016/j.molcel.2019.10.025

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Deadline: 19-05-2024

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