Antibody Scientist - Biotechnology

工作内容

Mantell Associates is currently partnered with this Cell Therapy Biotechnology organisation, who are searching for an Antibody Scientist to join their team.

Antibody Scientist - Responsibilities:

• Pave the way with cutting-edge research in antibody DNA synthesis, expression, purification, and characterization (e.g. stability and affinity)
• Develop these methods into efficient, robust, and cost-effective workflows that integrate well with our BioFoundry
• Innovate on existing methods and workflows to further decrease variance, costs, turnaround time, and/or increase throughput
• Setup ultra-high throughput experiments for large-scale antibody characterization (e.g. Tite-Seq or AlphaSeq)
• Utilize state-of-the-art technologies and automation to run high-throughput workflows that are fast and efficient, and generate high-quality data
• Be the go-to antibody expert, communicating your successes, results, and challenges across our interdisciplinary team
• Create standard operating procedures for the innovative workflows you develop

Antibody Scientist - Requirements:

• PhD or equivalent experience in molecular biology, biochemistry, enzymology, metabolic engineering, biophysics, or related fields
• Proven expertise in antibody expression, purification, screening and characterisation (scFvs, VHHs, etc) with in vitro and/or in vivo protein expression systems
• In-depth experience with different protein purification techniques (e.g. affinity tag purification, protein A/G chromatography) and biophysical antibody characterization techniques (SPR, BLI, DLS, ELISA, etc.)
• A successful track record in antibody optimization including affinity maturation, stability and aggregation determination and functional assays
• Excitement to learn, contribute, and drive innovation in an early stage startup environment. Having an appetite for its ambiguity and fast pace
• Hands-on experience expressing antibodies in mammalian cell systems (CHO/HEK293) preferable
• Familiarity with in vitro display technologies (phage display, yeast display) involving library design, construction, and screening preferable
• Working knowledge of structural biology and protein computational modeling approaches (e.g. Rosetta, Visual Molecular Dynamics, PyMol, RasMol, UCSF Chimera, Crystal Studio) preferable
• Experience with statistical approaches and next-gen sequencing techniques (Illumina, NanoPore, PacBio) preferable

Mantell Associates is a specialist Pharmaceutical and Life Science headhunting firm. For more information on this oportunity, contact us at +44 (0)20 3854 7700.