Discovery Scientist - Neuroscience and Rare Diseases Brain Delivery

Job content

The PositionIn Roche´s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.Role MissionWe are seeking an independent and creative scientist with unique experience to drive exploratory research and drug discovery efforts for neurodegenerative disease projects, with a strong focus on the blood-brain barrier. We are a multidisciplinary team focused on advancing cutting-edge technologies to improve the delivery of antibodies to the brain in order to develop novel therapies for neurodegenerative disorders. In a highly cross-functional and collaborative environment, you will have the opportunity to work on innovative approaches to develop the next generation of Brain Shuttle-based treatments for patients with devastating neurologic disorders.Your Impact

• Develop novel tools to investigate receptor cell biology at the blood-brain barrier
• Validate the use of in vitro blood-brain barrier models for molecule profiling and new target discovery
• Actively contribute to ongoing efforts on receptor discovery and/or characterization with hands-on experimental work or through establishment of academic collaborations
• Lead and support translational research projects, including championing a strategic research plan, leading a cross-functional project team of preclinical scientists, reporting on progress to a diverse group of basic and clinical scientists, as well as defining deliverables and deadlines
• Independently design, execute, analyze, interpret and communicate experiments
• Demonstrate scientific excellence by publishing and presenting at scientific meetings

Your Profile

• PhD in Cell Biology, Neuroscience or other relevant areas with substantial post-doctoral and industry experience.
• Outstanding track record of expertise in human in vitro models (e.g. organoids, microfluidic chips) and their application to address therapeutically relevant questions in Neuroscience.
• Deep expertise in cell biology methods to investigate transmembrane receptors, including biochemical, proteomic and transcriptomic approaches
• Experience with generating and characterizing disease models will be an advantage
• Flexible mindset to work on innovative platform approaches as well as different projects/molecules, with the motivation for problem solving and generation of high quality data packages
• Strong critical thinking, communication, organization, and presentation skills
• Driven by scientific curiosity and commitment to patients

Our commitmentRoche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career.We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.Who we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.Roche is an Equal Opportunity Employer.