Drug Metabolism, Enzymology & DDI Scientist

☞ Roche

View: 164

Update day: 29-03-2024

Location: Basel Basel-Stadt BS

Category: R & D IT - Software

Industry: Medical Equipment Biotechnology Research Pharmaceutical Manufacturing

Job type: Full-time

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Job content



At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.
That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located in ADME, a chapter within global Pharmaceutical Sciences, where the fate of new chemical entities and biologics is a primary focus. The ADME Chapter works throughout all stages of compound development, from lead optimization to candidate selection, all clinical development phases to filing of new drug applications. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

Job mission

The Scientist Drug Metabolism, Enzymology & DDI will ensure the right approaches to assess the disposition of our new small molecule drug research and development candidates focusing on metabolic enzymes and related potential liabilities for the patient.

Your impact

  • The responsibility of the job encompasses the set-up, validation and application of standard as well as state-of-the-art methodologies to assess the disposition and DDI liabilities of our new small molecule drug candidates to predict and reduce potential liabilities for the patient.

  • Projects in scope range from early discovery up to regulatory submission stage. You will develop and communicate experimental strategies, run and/or monitor the in vitro assays, document results and provide the data interpretation with the different partners.

  • The development of new, innovative in vitro tools and approaches to fill out the latest gaps in the field are equally part of this job to assure implementation of the best at Roche.



Your profile

  • You hold a PhD in biochemistry or related relevant discipline with in-depth knowledge and several years of practical experience (preferably industrial) in the area of drug metabolism, enzymology, and inhibition/induction.

  • You are familiar with common digital tools for experimental planning, FAIR data capturing, evaluation and reporting in data bases and reports.

  • Preferably you gained hands-on experience with quantitative LC-mass spectrometry, radio-HPLC and/or in silico prediction methodologies (e.g. PBPK) for human PK prediction and DDI risk assessment.

  • You are committed to work in a team and are focused to drive the portfolio forward with the best approaches available.

Your location
The position will be located in Basel

You’re someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you.

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Level:

Individual contributor
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Deadline: 13-05-2024

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