In vitro ADME of Biologics Senior Associate

Job content

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.
That is why we come to work each day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

In Roche’s Pharmaceutical Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

This position is located in ADME, a chapter within global Pharmaceutical Sciences, where the fate of new chemical entities and biologics is a primary focus. The ADME Chapter works throughout all stages of compound development, from lead optimization to candidate selection, all clinical development phases to filing of new drug applications. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

Job mission

The Senior Associate in vitro ADME of biologics will generate experimental data following the highest scientific quality standards in order to assess the disposition of new biologics R&D candidates across multiple disease areas. The main focus areas will be tissue targeting, intracellular trafficking and target-mediated disposition processes assessed in complex cellular models.

Your impact

• Together with a multidisciplinary team, you use state-of-the-art methodologies (e.g. complex cellular models, microphysiological systems, imaging) to assess receptor-mediated processes driving PK/PD relationships of new biologics drug candidates.
  
  

• You apply diverse in vitro models (primary cells and cell lines) as well as quantitative methodologies (biochemical and microscopy assays) to support projects across the portfolio. You document the experimental setup, protocols and results with the highest scientific standards.
  
  

• You maintain state-of-the-art lab infrastructure, materials and analytical instruments.
  
  

Your profile

• You hold a bachelor or master in biochemistry, molecular biology or related relevant discipline with in-depth practical experience (preferably in industry) in cell culture and molecular biology, in particular using analytical methods to investigate proteins (ELISA, Western Blot, microscopy). Experience in advanced cell models (organoids, microphysiological systems) will be an asset.
  
  

• You are familiar with common digital tools for experimental planning, FAIR data capturing, evaluation and reporting in databases and reports.
  
  

• You are committed to work in a team and are focused to drive the portfolio forward with the best approaches available.
  
  

Your location
The position will be located in Basel

You’re someone who wants to influence your own development. You are looking for a company where you receive the opportunity to pursue your interests across functions and geographies. Working in a multi-cultural environment motivates you.

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Job Level:

Individual contributor