Internship in Investigative and Immunosafety (from July 2023; for 9-12 months )

Job content

The PositionRoche Pharma Research and Early Development (pRED) is currently seeking an intern with a background in cellular biology and bioengineering to join their Investigative and Immune Safety department in Basel, Switzerland. The department is dedicated to the development of innovative in vitro systems for assessing drug safety and efficacy.Complex in vitromodels of the vasculature are versatile systems that can be applied to various areas and stages of the drug development process and facilitate highly physiological and relevant readouts such as safety, efficacy, and pharmacokinetics/pharmacodynamics (PKPD). Furthermore these systems can provide highly relevant readouts of immune cell adhesion and transmigration. The team has developed an innovative and robust microvascular platform on organoid vascularization, which is being used to support portfolio projects within pRED.As an intern, you’ll work with a highly specialized team focused on developing advanced human cellular models of the tumor microenvironment, with a particular emphasis on the vasculature. You’ll gain hands-on experience with cutting-edge organ-on-chip platforms and various 2D and 3D cell culture setups. You’ll also have the opportunity to help expand the use of the microvascular platform and leverage the generated in vitro data which is essential in supporting decision-making processes for molecules in Roche’s drug development pipeline.The role of the internship studentAs an intern, you will mainly be involved in wet lab activities around the vascular model. You’ll assemble and maintain the system, apply portfolio molecules, and use techniques like immunostainings, microscopy, cytokine measurements, and FACS. You’ll also analyze experiments using image quantification and FlowJo. It’s a unique opportunity to gain real-world experience in a state-of-the-art lab and contribute to cutting-edge drug therapiesMain tasks

• 2D and 3D Cell culture
• Design, execute and analyze experimental work with the supervision of different team members
• Assist with the development and application of advanced in vitro micro physiological models of the tumor microenvironment
• Contribute to the lab and team organization
• Ensure proper documentation and evaluation of raw data

Requirements

• You are enrolled in a MSc program (or completed your studies within the last 12 months) in cellular/molecular biology or related field
• Previous experience in working in a cell culture laboratory is required (BSL2)
• Experience with organoids, isolation of primary cells and in-vitro microphysiological systems such as Organs-on-a-chip is a plus
• Previous experience with confocal microscopy and/or FACS is desired, but not mandatory
• Good organizational skills
• Fluency in English is mandatory

Start date: July 2023 or upon availabilityDuration:9-12 monthsWorkload: 100% - 40 hours a week. Please consider that working part time is not an option at this position.Who we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.Roche is an Equal Opportunity Employer.