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Internship/Master’s project for Biology or Biochemistry students - mitochondrial phenotype analysis in neurodegenerative disease models
View: 127
Update day: 26-03-2024
Location: Basel Basel-Stadt BS
Category: Education / Training
Industry: Medical Equipment Manufacturing Biotechnology Research Pharmaceutical Manufacturing
Position: Entry level
Job type: Full-time
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Job content
The PositionIn Roche’s Pharmaceutical Research and Early Development organization (pRED ), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.Within Roche’s Pharma Research and Early Development (pRED), Neuroscience & Rare Diseases (NRD) represents a major focus area where we are committed to realizing our long-term vision of changing lives of patients with severe brain disorders. Our preclinical research and early clinical development activities center around large and rare indications within the four major pillars of neurodevelopmental disorders, movement disorders, dementias, and multiple sclerosis. With unparalleled strengths across diverse disciplines, Roche is uniquely positioned to lead in transforming science to medicines for patients with disorders of the nervous system. This position is located in the Exploratory Neurobiology Section within the Neuroscience and Rare Diseases (NRD) in Basel, Switzerland. The Exploratory Neurobiology Section focuses on understanding the pathomechanisms related to neurodegenerative disorders such as Alzheimer’s and Parkinson’s Disease and the development of novel therapeutics.Job missionWe are looking for a highly motivated intern (currently enrolled in a Bachelor/Master program, or recently graduated) with high interest and determination to improve the lives of patients suffering from devastating neurodegenerative disorders. You will benefit from the supervision of experienced scientists focusing on the establishment of mitochondrial functional assays to investigate the mitochondria phenotype in neurodegenerative disease models. You will have the opportunity to join a world-leading industry setting and contribute to changing the lives of patients. You will be part of an existing research lab and have the full opportunity to work in close collaboration with multidisciplinary experts to reach all together our goal to provide patients with innovative, safe and life changing treatments.During the internship your tasks will include:- Phenotypic and functional characterization of iPSC-derived neuronal and glial cells and understanding the effect of pharmacological or genetic modifications on mitochondrial function
- Design, preparation and execution of experiments and data interpretation
- Present your progress and data at internal meetings
- High commitment to work with a proactive mindset and in close collaboration with the team and project members in order to effectively advance exploratory projects
- A biology, biotechnology, biochemistry, or molecular biology student enrolled in a Master degree program, or you are a recent graduate from a Master program (within 12 months)
- Solid understanding of cell / molecular biology including mitochondrial / lysosomal function
- Highly motivated individual eager to learn and establish cutting-edge techniques
- Self-motivated and independent thinker with excellent communication skills, attention to detail, and the desire to work in a fast-paced, cutting-edge environment
- Practical experiences with mammalian cell culture and AAV viral vectors
- Experience in pluripotent stem cell cultivation, in vitro differentiation towards neurons and glia, as well as cellular and molecular characterization thereof
- Expert user of imaging tools such as for example confocal or high-content imaging with image analysis
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Deadline: 10-05-2024
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