(Senior) Scientist, Analytical Development

Job content

Matterhorn Biosciences is looking for a (Senior) Scientist, Analytical Development.

Matterhorn Biosciences is a preclinical stage biotechnology company pioneering the discovery and development of novel T cell therapy for cancer treatment. We are an exciting motivated group of scientists who are determined to make a difference for modern human medicine.

As we continue to build the Process Development team, we are seeking a highly motivated scientist to join our team as a (Senior) Scientist, Analytical Development, supporting the development of novel T cell therapies in house. The role will require the precise application of a diverse range of laboratory-based skills. As such, the successful candidate will have significant experience on development and optimization of analytical methods. The ideal candidate should be highly motivated, enthusiastic with a positive “can do” attitude, hands-on, strong organizational skills, able to work independently and enjoy fast-paced, collaborative, and vibrant start-up culture.

Responsibilities

• Develop analytical methods for engineered T Cells and starting material
• Execute a variety of analytical methods, including cell-based assays, flow cytometry, d/qPCR and ELISAs
• Culture of primary immune cells and cell lines
• Optimization and validation of analytical methods
• Ensure suitable documentation of experiments and methods
• Support the quality control (sampling/ testing) of manufacturing process development
• Support technology transfer of analytical methods to contract manufacturing organization
• Oversight and management of external test labs
• Evaluate new technologies for release and characterization testing
• Generation and maintenance of SOPs, protocols and technical reports
• Provide mentorship and training for junior team members, and coordinate and prioritize work to meet timelines
• Analyze data, make figures for presentation, and present at group and company meetings
  

Qualifications

You have significant laboratory experience, along with a good understanding of the assays used in a molecular and cellular immunology laboratory. Specifically, we are looking for candidates with the following:

• Master’s or PhD degree in chemical/ biochemical engineering, biochemistry, biology or a related scientific discipline
• Master’s with 6+ years or PhD with 2+ years of relevant experience, preferably in biopharmaceutical or biotechnology industry
• Strong background in tumor immunology, T cell therapy (TCRs/CAR-T cells), T cell biology
• Solid Hands-on experience with immunological and biochemical methods FACS, PCR, cell culture, cytotoxicity assays, ELISA
• Strong technical writing skills with industry experience writing technical protocols, reports, and procedures required
• A working knowledge of manufacturing and/ or testing of cell therapy products and/ or ATMPs is preferred
• Experience of analytical method qualification/validation is desired
• Knowledge of quality systems and documentation requirements is a plus
• Knowledge of compendial analytical methods (Ph. Eur. / USP) is preferred
• Know-how experimental design and ability to work independently
• Able to work in a highly flexible environment
• Able to communicate with team members and cross-functional project teams
• Strong attention to detail
• Highly self-motivated and able to motivate others
• Good English communication skills, both oral and written
  

What We Currently Offer

• Offices: Our well-equipped laboratories and offices are located at the Tech Park Basel, a premier address for early-stage start-ups.
• Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
• Flexible Working: We support flexible working as appropriate.
• Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
• Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
• Food: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
• Coffee: Meet up with your colleagues and grab free coffee.
• Development: We support the individual development of our employees.
• German Lessons: For our international employees we support German lessons to speed up integration.
• Creativity: We offer an innovative and creative environment.
• People: We are an international and diverse team with talented and passionate people.
• Fun: From time-to-time we organise cool off-site summer and winter team events.
  

To apply, please send us this application form together with your CVand Cover Letter.