Senior Scientist, Nonclinical DMPK

Job content

Debiopharmis an independent biopharmaceutical company based in Switzerland with an ongoing commitment to research in oncology and bacterial infections in order to improve patient outcomes and quality of life. Our main activities include drug development, drug manufacturing and digital health investment. Debiopharm International SA aims to develop innovative therapies that target high unmet medical needs. Bridging the gap between disruptive discovery products and real-world patient reach, we identify high-potential compounds for in-licensing, clinically demonstrate their safety and efficacy and then select large pharmaceutical commercialization partners to maximize patient access globally.

Here:https://apply.workable.com/debiopharm-group-sa/

For our Translational Medicine organization based at our Headquarters in Lausanne, we are looking for a

Senior Scientist, Nonclinical DMPK

In this role, you will represent the Clinical Pharmacology & Drug Metabolism function in Translational Medicine team or project teams and contribute to the development of new antibiotics and innovative medicines in oncology.

Your responsibilities will be but not limited to:

• Design, plan, manage, and report the nonclinical DMPK studies:
  • Exploratory DMPK studies to support innovation projects
  • In vitro and in vivo DMPK profiling to support lead optimisation and selection of drug development candidates
  • In vitro and in vivo DMPK (including toxicokinetics) regulatory and nonregulatory studies to characterise the ADME properties and the risk of drug-drug interactions of drugs in development
  • Modelling and simulation of nonclinical data (such as allometric scaling, PBPK modelling, nonclinical PK/PD) to support human dose prediction
• Manage outsourcing activities to an international network of CROs or through academic collaborations (request for proposal, contractor selection, contract review and budget negotiation)
• Manage finance, budget and timelines related to assigned nonclinical DMPK activities
• Contribute to the preparation of the nonclinical DMPK documentation to support the cross-functional activities (including nonclinical DMPK chapters of regulatory documents or patents)
• Participate in external scientific communications (publications, poster and oral presentations, and press releases)
• Contribute to in/out licensing activities and external fund-raising activities (evaluation of new external opportunities, participation in due diligences and grant applications)

Requirements:

• PhD, engineer degree or equivalent in pharmacokinetics, pharmacology, life sciences or a related discipline with 5-7 years’ experience in nonclinical DMPK within Translational R&D
• Knowledge of GLP and ICH guidelines; animal welfare regulations
• Fluency in English (both oral and written)
• Very good communication skills & influencing skills (oral and written)
• Strong team player, looking to drive further projects and innovation
• Project management experience
• Team management and leadership experience is a plus

Benefits:

• An international and highly dynamic environment, with a long-term vision.
• The opportunity to join a successful company, at the forefront of the most advanced scientific developments in the industry and be exposed to many areas within clinical development and the pharmaceutical industry.
• The possibility to be in a company in which innovation, people and entrepreneurship are the fundamentals of its success.

The use of external staffing agencies or recruiters requires prior approval from our Human Resources Department. The Human Resources Department at Debiopharm requests external staffing agencies or recruiters not to contact Debiopharm employees or members of the Board of Directors directly in an attempt to present candidates.

Submission of unsolicited resumes in advance of an agreement between the Human Resources Department and the external staffing agency or recruiter does not create any implied obligation on the part of Debiopharm.

Debiopharm will not accept unsolicited resumes from any source other than candidates themselves for either current or future positions.