Student Internship in Protein Science and Structural Biology (from September 2023, 6 Months) (m/f/d)

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The PositionThe Lead Discovery Department in Small Molecule Research is part of Therapeutic Modalities (TMo) within Roche Pharma Research and Early Development (pRED). We deliver leading edge science to drive the success of Roche’s early pipeline discovery research activities through a strong expertise in high throughput or focused screening platforms, DNA encoded library technology, protein science & enzymology/biophysics, cell-based assays and biostructure determination. We are accountable for the provision of high quality chemistry starting points for Small Molecule projects and generating molecular and mechanistic insights that are critical for the advancement of discovery projects. During the internship, you will:

• Actively contribute to an early-stage technology development project
• Apply and develop biochemical tools for membrane protein purification and structure determination by cryo-electron microscopy in a top notch facility
• Learn a broad spectrum of methods to characterize the stability and enzymatic activity of proteins, and analyze interactions with small-molecule ligands
• Get hands-on experience on laboratory automation and robotics
• Plan experiments and present your findings in group seminars
• Learn about the function of a research department in the pharmaceutical industry

Who you are:You are someone who wants to influence your own development, and you seek for a work experience in a company that will give you the opportunity to pursue your interests across functions within a dynamic research environment. As an enthusiastic and proactive Master student in the area of biochemistry or related fields with prior experimental know-how in protein purification and characterization, you are highly motivated, interested in a multidisciplinary and multinational environment, and you wish to expand your technical skills in the laboratory.We are looking for an aspiring scientist with:

• Technical experience in protein purification and analytical methods such as affinity/size exclusion chromatography and SDS-PAGE
• Structure determination experience and general education in protein structure are a plus
• Experience in working with membrane proteins, in particular GPCRs, is a plus
• Excellent organizational skills and a pro-active attitude
• Motivated and focused, able to multitask, and meets timelines efficiently and productively
• Fluent in English (German is a plus)
• Master of Science student (M.Sc.) with proof of academic excellence and enrolled in a University with the goal to pursue a career in the Life Sciences field

The Internship can start between September and October 2023 - please clearly indicate your preferred starting date in your motivation letter. Applications must include a CV, motivation letter and certificate of enrollment in one merged PDF document.Due to regulations non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory as part of the application documents.Should you have any questions, please check our FAQs and videos at careers.roche.ch/faqWho we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche.Roche is an Equal Opportunity Employer.