Expert – Upstream Process Development (m/f/d)

☞ Novartis

View: 146

Update day: 24-04-2024

Location: Basel Basel-Stadt BS

Category: Executive management Production / Operation

Industry: Pharmaceuticals

Position: Mid-Senior level

Job type: Full-time

Loading ...

Job content

Job Description

50+! The number of New Biological Entities currently in early development awaiting to be transformed into successful high quality innovative medicines and in need of Experts in charge of the cell culture process development, starting from initial clone selection until the transfer to commercial production.

As a member of the USP technical team for Drug Substance Development (DSD), you will support the development and improvement of cell culture processes as well as the exploration of new technologies for therapeutic protein production.

In this scope, you will e.g.:
  • Support the development of efficient, high-yielding, robust and scalable fermentation processes for new biological entities, the process transfer to large scale, process characterization and validation
  • Design, plan, perform, and evaluate parallelized cell culture experiments at lab scale (small to bench-top)
  • Support the exploration, implementation, and improvement of established fed-batch and (semi) continuous perfusion cell culture processes, including technological applications, from vial break to harvest
  • Write protocols, basic scientific reports, lab procedures or SOPs; contribute to scientific documents intended for internal and external partners, or for generation of registration documents
  • Work in multidisciplinary, international teams, and actively contribute to project teams as USP expert. Interface with related drug substance process development and analytical functions.
Major accountabilities
  • Design, plan and implement USP lab activities, primarily parallel fermentation experiments, in our lab scale (<10 L) facility using innovative disposable and glass bioreactor technology.
  • Record experimental data in the respective data management systems. Review and verify raw data generated by others.
  • Generate and review technical or scientific documents, such as study plans and reports, development reports, risk assessments as part of our development projects.
  • Actively communicate and present your results in project teams.
  • Look after USP laboratory equipment.
  • Work according to appropriate standards defined for quality, ethics, health, safety, environment, and information security.
Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

Requirements

Minimum requirements

Minimum:
  • Bachelor of Science in Life Sciences (e.g. Biotechnology, Biochemistry or Bioengineering) with knowledge and basic laboratory experience in upstream processing (i.e. aseptic handling of mammalian cells) or equivalent education/experience in an industrial setting
  • Intrinsic curiosity, willingness to adopt challenging tasks and grow in related areas of expertise (e.g. parallelized, automated fermentation)
  • Proficiency in English (both spoken & written)
Desirable:
  • Master of Science in Life Sciences (e.g. Biotechnology, Biochemistry or Bioengineering) with a profound background in upstream processing
  • Broad experience with upstream processing with mammalian cell cultures in bioreactors and statistical methods (DoE, MVDA)
  • Proficiency in German is an advantage
Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Division

Global Drug Development

Business Unit

TECHNICAL R & D GDD

Country

Switzerland

Work Location

Basel

Company/Legal Entity

Novartis Pharma AG

Functional Area

Research & Development

Job Type

Full Time

Employment Type

Regular

Shift Work

No

Early Talent

Yes
Loading ...
Loading ...

Deadline: 08-06-2024

Click to apply for free candidate

Apply

Report job
Loading ...
Loading ...

SIMILAR JOBS

Loading ...
Loading ...