Principal Scientist

Job content

Alentis Therapeutics is developing breakthrough treatments for fibrotic and rare diseases and associated cancers. The company’s lead candidates are monoclonal antibodies that are highly selective for exposed and non-junctional Claudin-1 (CLDN1). Non-junctional CLDN1 is a previously unexploited target with a unique mechanism of action that plays a key role in the pathology of kidney, lung, and liver fibrosis, as well as solid tumors.

Alentis` lead therapeutic program, ALE.F02, has finished recruitment into a Ph1a study in healthy volunteers and is currently being developed for the treatment of advanced fibrotic diseases. ALE.C04 will enter clinical studies in oncology in 2023.

Tasks

• Lead a team of cell biologists responsible for discovering clinical biomarkers, exploring oncology/fibrosis mechanism of actions, and progressing projects from concept to clinical testing
• Lead and liaise with multi-disciplinary activities (Bioinformatics, Pharmacology, ADME/PK/Tox…) to drive drug discovery projects forward
• Generate robust data package to support the entry of new company’s drug assets in discovery portfolio
• Identify, develop, and implement cellular assay cascades to support the initiation and advancement of projects
• Provide experimental and scientific leadership to the team
• Foster innovation in the team and contribute to new targets and approaches
• Present to Senior Leadership Meetings
• Engage key opinion leaders and set-up external collaborations with academic institutions and external CROs
• Set-up team strategy and guide an experimental roadmap to support quick Go/No Go decisions in drug discovery projects and high-quality execution of the Therapeutic Area goals
• Ensure a high-level scientific standard is maintained on all projects
• Ensure smooth communication and interactions with the other teams and all stakeholders
  
  

Requirements

• Ph.D. in Natural Science
• At least 8 years Industrial experience in biotech/pharma or CRO in drug development
• Minimum 5 years of drug discovery experience in Fibrosis and/or Oncology
• Track record of leading Large Molecules projects towards clinical candidate nomination
• Previous management experience in pharmaceutical or biotechnology industry
• Strong understanding of fibrosis and/or cancer biology and drug discovery landscape
• Demonstrated ability to lead multiple drug discovery projects and external collaborations
• Independent scientist with the ability to adapt and prioritize activities to challenging deliverables
• Creative and able to bring new ideas
• Passionate about bringing new transformative medicines to fibrosis and cancer patients
• Team player with good interpersonal skills, able to work efficiently in a multidisciplinary environment
• Proven ability to design and execute science-driven, outcome-focused experimental protocols
• Ability to write reports and accurate records of scientific data
• High level conceptual and critical scientific thinking, which is used to solve complex issues and their implications in the drug development process
• Excellent communication skills in English, written and verbal
• Good organizational skills
• Ability to multi-task and prioritize assignments
• A proactive attitude and willingness to learn and carry out new and complex tasks
• Self-motivation and the ability to work independently in a fast-pace, small company environment
  
  

Benefits

• The opportunity to contribute to the development of First-In-Class molecules in an innovative leading Biotech environment in the field of fibrosis and oncology
• Competitive compensation for your work and a flexible working environment
  
  

Alentis Therapeutics is a clinical-stage biopharmaceutical company developing breakthrough treatments for cancer and fibrotic diseases.