Research Associate - Therapeutic RNA Scientist (80-100%*)

☞ Novartis

View: 148

Update day: 25-04-2024

Location: Basel Basel-Stadt BS

Category: Health / Medical Care

Industry: Pharmaceutical Manufacturing

Position: Associate

Job type: Full-time

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Job content

Job Description

70! That’s the number of Scientists in the Novartis Institutes of Biomedical Research who are focused on developing the next generation of siRNA therapies with the potential to help produce therapeutic breakthroughs for patients to treat previously undruggable diseases.

We are seeking a highly motivated scientist with at least 3 years of experience in pre-clinical pharmaceutical development to join the Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC in Basel, Switzerland.

The BEGT group drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and AAV. Through innovative and rational modality design, the BEGT group works collaboratively with Disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations. The ideal candidate will have a proven track record in evaluation of bio-conjugate therapeutics. Hands-on experience in cell culture, compound analytics and molecular biology techniques are a plus

Your responsibilities will include:
  • Support assays for quantification, construct validation and stability oligonucleotide conjugate constructs.
  • Perform gene expression and functional analysis by various methods.
  • Preform cellular internalisation and in vitro toxicity assays.
  • Provide technical reports and documentation accurately and on time.
Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.

Minimum Requirements

What you will bring to the role:
  • Hands on lab experience with cell culture, RNA isolation, real-time qRT-PCR, ELISA, western blot, immunohistochemistry and flow cytometry.
  • Expertise in the cellular and functional characterization of oligonucleotides and prior experience with shRNA and AAV technologies are a plus.
  • Capability of running experiments independently
  • Highly collaborative spirit in- and outside of department to advance programs to clinic, strong communication skills, creativity, and multi-tasking in a fast-paced environment
Desirable requirements:
  • MS degree in pharmaceutical sciences, biochemistry, molecular or cell biology, or a related field, or a BS degree, relevant laboratory experience.
Why consider Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what’s possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to learn more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network
  • Some restrictions on flexible working options may apply and will be discussed during interview if applicable.
Division

NIBR

Business Unit

Biotherapeutic And Analytical Technologies - Nibr

Country

Switzerland

Work Location

Basel

Company/Legal Entity

Novartis Pharma AG

Functional Area

Research & Development

Job Type

Full Time

Employment Type

Regular

Shift Work

No

Early Talent

No
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Deadline: 09-06-2024

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